Radiation effects on submandibular gland of the rat. Stereological and ultrastructural study

Abstract

The chronic effect of 2000rd (20Gy) of X-rays locally applied to the submandibular gland of Wistar young adult male rats, was studied by stereology, and light and electron microscopy observations. They demonstrated that degenerative changes were observed during the first months after irradiation. A trophic processes developed from 6 months onwards. In the acinar compartment atrophy was progressive from the first months post-irradiation up to 9 months post-irradiation. Ductal cell membranes and mitochondrial demage were clearly detected ultrastructural level. Nuclear fragmentation and secretory granules alterations were also frequently seen in the acinar compartment.