Study of some variables which influence the labelling iodoantipyrine 131I

Abstract

Several methods have been published for the prepara-tion of 4-iodo 2-3 dimethyl phenyl pyrazolone (iodo-antipyrine) [1, 2, 3] but none of them mention the experimental procedures involved nor the yield obtain-ed, with the exception of ref. [3], which employs the Conway camera microdiffusion method, with a yield of 30%. We have studied the influence of some variables on the yield of labelled iodoantipyrine, obtained by isotopic exchange according to the method of MITTA and GAMIN [4]. In particular we have studied the influence of ρκ, concentration, temperature and illumination.