Determination of inoganic radioiodide in 131 I-labelled compounds by means of thin-layer chromatography

Abstract

Organic compounds labelled with a radioiodide for use in medical diagnosis or therapy generally contain inorganic radioiodide as their main impurity. According to current regulations, the radioiodide content should never exceed 5 %. Several techniques are used for the determination of inorganic radioiodide, viz. paper chromatography, paper electrophoresis, thin-layer chromatography, precipitation, thin-layer electrophoresis, etc. Several authors, pharmacopeias, Atomic Energy Commissions and commercial firms such as Squibb, Abbott. Amersham, Hoechst, etc. have published on this topic 1-10.