A chromatographic method for the study of the stability of labeled sodium polymetaphosphate

Abstract

Ascending chromatography method developed on the basis of the Ebel technique provided us with a good and easy technique for the differential analysis of the mixture of phosphates in the case of sodium polymetaphosphate labeled with radiophosphorus. This radiopharmaceutical, used extensively in clinical work for the treatment of bone cancer, is therapeutically efficient only with a high ratio of highly condensed molecules. This method, carried out as a radiometric determination, gives us values close to the photocolorimetric method values.