Polymerase-functionalized hierarchical mesoporous titania thin films: Towards a nanoreactor platform for DNA amplification

Abstract

Nucleic acids are essential in life, as they control the functioning of the cells and carry the genetic information. DNA manipulation has become one of the most active research areas of current science. As a consequence, the development of advanced platforms able to interact with DNA is blooming. [1] Integration of novel nanomaterials with advanced molecular biology techniques constitutes one of the main targets of nanobiotechnology. Here we report that polymerase-containing titania thin films of appropriate hierarchical nanoporous architecture are capable of performing DNA amplification.