A chromatographic study of the stability of Iodine-131 labeled Sodium o-Iodohippurate

Abstract

A series of experiments have been canied cut in order to study the stability of sodium o-iodohippurate (Hippuran) labeled with iodine. Solutions of sodium o-iodohippurate 1-131 in pharmaceutical form are widely used as a radioisotopic diagnostic agent in kidney function studies. The purpose of the experimental work was to determine the stability of the radioactive material under various conditions of pH, salt concentration, and time. Assays were carried out using sodium o-iodohippurate labeled with 1-131 by exchange (1 ). Preparations possessing different specific activities were tested in order to detennine the effect of specific activity on the rate of decomposition of the product.